A common compound: 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1074-82-4
General procedure: 1,2-dibromoethane (258 uL, 3.0 mmol), KI (66 mg, 0.4 mmol) and K2CO3 (414 mg, 3.0 mmol) were added to a 15 mL sealed tube, followed by the addition of potassium phthalimide (370 mg, 2.0 mmol). Then 8.0 mL acetone 2a was added to the reaction system. The mixed solution was stirred at 60 C under air conditions. Completion of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was diluted with 100 mL water and extracted with 50 mL ethyl acetate. The organic layer was dried over anhydrous Na2SO4, evaporated under reduced pressure and separated by column chromatography on silica gel (200-300) with petroleum ether/ethyl acetate mixtures to obtain the desired product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1074-82-4, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Xujie; Li, Gangsheng; Yang, Yanan; Jiang, Jianshuang; Feng, Ziming; Zhang, Peicheng; Chinese Chemical Letters; vol. 31; 3; (2020); p. 711 – 714;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem