In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141452-01-9 as follows. SDS of cas: 141452-01-9
Preparation of Intermediate 1-(4′-Trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester (I-5b) 4′-Trifluoromethyl-biphenyl-2-carboxylic acid (4.51 g, 16.9 mmol) and 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester I-5a (3.0 g, 16.9 mmol) were dissolved in DCM (50 ml). PyBroP (8.4, 18 mmol) and hunig’s base (2.58 g, 20 mmol) were added to the above mixture the reaction mixture was stirred overnight. PyBroP (4 g) was added to the reaction mixture and the reaction mixture was stirred overnight.The reaction mixture was diluted with DCM (200 ML) and washed with a saturated solution of NaHCO3 (100 ml*3), HCl (1N, 150 ml*2).The organic layer was collected and dried (Na2SO4).The solvent was removed under reduced pressure and the residue was purified by flash chromatography to provide the desired product 3.5 g.
According to the analysis of related databases, 141452-01-9, the application of this compound in the production field has become more and more popular.