Adding a certain compound to certain chemical reactions, such as: 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5394-18-3, Formula: C12H12BrNO2
Cs2C03 (2 eq) was added to a solution of an alkyl bromide of general formula (IX) (1 eq) and amine of general formula (VIII) (1.1 eq.) in dry DMF with stirring. The mixture was stirred at 70C overnight or until consumption of the alkyl bromide. The reaction mixture was concentrated, extracted with EtOAc/H20. The organic phase was washed with brine, dried (MgS04), concentrated and purified by chromatography (mixtures of petroleum ether and EtOAc) to afford the bis-protected intermediate. General procedure 3 (alkylation). Starting materials: compound 2 and tert-butyl piperazine- 1-carboxylate.^-NMR (CDCI3) : delta 7.84 (m, 2H), 7.71 (m, 2H), 3.71 (t, 2H), 3.41 (t, 4H), 2.37 (m, 6H), 1.71 (m, 2H), 1.53 (m, 2H), 1.45 (s, 9H).
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