Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 552330-86-6, name is 5-Bromoisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Bromoisoindolin-1-one
In a screw cap vial under an argon atmosphere 3,4-dimethoxy-2- (isobutoxy)phenylboronic acid (Compound 302) (0.015g, 0.06mmol) and the bromide (0.066 mmol) was dissolved in dimethoxyethane (0.35 mL). K2C03 (1M solution, 0.12 mL, 0.12 mmol) and Pd(PPh3)4 (0.004g, 0.003mmol) was added. The suspension was shaken at 80C for 72h. Brine (2 mL) was added and the mixture was extracted with CH2CI2 (3 mL). The phases were separated using a phase separation cartridge (Chromabond, PTS) . The organic phase was concentrated in vacuo and the residue was dissolved in DMF (0.3 mL) and purified by preparative HPLC/MS.Compounds 174 – 176 were prepared according to this procedure: -i2-Isobutoxy-3r4-dimethoxy-phenyl)-2,3-dihydro-isoindol-l-one iCompound 174)1H NM (600 MHz, DMSO-SPE) delta 8.53 (s, 1H), 7.68 (d, J = 7.8 Hz, 1H), 7.64 (s, 1H), 7.56 (dd, J = 7.9, 1.2 Hz, 1H), 7.09 (d, J = 8.6 Hz, 1H), 6.93 – 6.88 (m, 1H), 4.39 (s, 2H), 3.84 (s, 3H), 3.79 (s, 3H), 3.48 (d, J = 14.4 Hz, 2H), 1.78 – 1.67 (m, 1H), 0.75 (d, J = 6.7 Hz, 6H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 552330-86-6.