1074-82-4, Adding a certain compound to certain chemical reactions, such as: 1074-82-4, name is Potassium 1,3-dioxoisoindolin-2-ide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1074-82-4.
[00651] A mixture of chioroacetone 88 (3.20 g, 34.8 mmol, 1.0 eq) and potassium 1,3- dioxoisoindolin-2-ide (6.43 g, 34.8 mmol, 1.0 eq) in DMF (10 mL) was stirred at 20 C overnight under nitrogen. The mixture was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, filtered, and concentrated. The residue was purified by SGC (petroleum ether / ethyl acetate, 6 / 1) to afford the desired product 89 (4.00 g, 19.7 mmols, 60.6%) as a white solid.[00652] LCMS: ESI-MS: m/z: 204.2 [M+H1 RT = 1.40 mm. (Method A)
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Reference:
Patent; ALPHARMAGEN, LLC; PUTMAN, David, G.; DASSE, Olivier; HOGENKAMP, Derk; (154 pag.)WO2016/144792; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem