Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32692-19-6, name is 5-Nitroindoline, A new synthetic method of this compound is introduced below., Safety of 5-Nitroindoline
Example 23 (S)-3,5-Dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)- phenyl)-2-(2-(5-(methylsulfonamido)indolin-1 -yl)acetoxy)ethyl)pyridine1 -oxide (Compound 131 ) Scheme 23 Step 1 : Preparation of benzyl 2-(5-nitroindolin-1 -yl)acetate (127) To a solution of 5-nitroindoline (1 g, 6.09 mmol) in dry DMF (20 ml), K2C03 (1 .094 g, 7.92 mmol) and benzyl 2-bromoacetate (1 .242 ml, 7.92 mmol) were added and the resulting suspension was heated at 65C for 2 hours. The mixture was cooled to room temperature, diluted with ethyl acetate and washed with water and brine. The organic layer was dried over sodium sulfate and the solvent was removed. The residue was purified by flash chromatography on silica gel column (DCM:petroleum ether = 60:40) affording benzyl 2-(5-nitroindolin-1 -yl)acetate (0.782 g, 2.504 mmol, 41 % yield). MS/ESI+ 312.9 [MH] +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.