Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, category: indolines-derivatives
Under nitrogen protection,2 g (0.011 mol) of 7-chloroisatinAnd 2.27 g (0.042 mol) of potassium borohydride were put into a dry four-necked flask,Cooled to -10 ° C or less,Stirring,To this was slowly added dropwise 25 mL of dry tetrahydrofuranAnd 3.5 g (0.025 mol) of borontrifluoride etherate,The whole process control temperature does not exceed -5 ,Reaction overnight,Reaction completed,A solution of 4.5 g of potassium hydrogensulfate and 50 mL of water was slowly added dropwise to the solution,The mixture was distilled by steam,The distillate was extracted with ethyl acetate,Dried over anhydrous magnesium sulfate,The solvent was distilled off,To give 1.18 g of white needles (yield 71.0percent).
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