2058-74-4, A common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, molecular formula is C9H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In the test tube (0.5 mmol) isatin or acenaphthoquinone with 0.5mmol active methylene and 0.5 mmol 1,3-dicarbonyl compounds/4Hcumarin/alpha naphtol and 0.5 mL urea:ChCl were added. The reaction mixture was stirred and heated to 80 C. The reaction completion was monitored by TLC. After reaction completion about 5 mL water was added to reaction mixture in the cases that the solid was obtained and the solid was filtered, and in the cases that a viscose liquid was obtained after water addition the ethyl acetate was added to extract the product and the organic layer was removed under vacuum. The products were recrystallized from ethanol to give pure corresponding compounds
The synthetic route of 1-Methylisatin has been constantly updated, and we look forward to future research findings.
Reference:
Article; Azizi, Najmedin; Dezfooli, Sahar; Mahmoudi Hashemi, Mohammad; Journal of Molecular Liquids; vol. 194; (2014); p. 62 – 67;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem