Reference of 675109-26-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 675109-26-9, name is 6-Bromoisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a degassed solution of 6-bromoisoindolin-1-one (0.7 g, 3.3 mmol), 1-Boc pperazine (0.921 g, 4.9 mmol) and sodium tert butoxide (0.95 g, 2.5 mmol) in toluene (10 mL),Pd2(dba)3 (0.151 g, 0.l6Smmol) and BINAP (0.205 g, 0.33 mmol) were added at rt and heated to 80 C overnight in sealed tube. Then the reaction mixture was filtered through celite and concentrated. Water (4 mL) was added and was extracted with EtOAc (2 x 10 mL). The combined organic layer was dried over Na2SO4 and concentrated under vacuum. The resulting crude product was purified by flash chromatography (Eluent: 5-6% MeOH inDCM). After evaporation, the resulting solid was triturated in Et20 and filtered, affording the title product (white solid). 1H NMR (400 MHz, CDCI3): 6 8.72-8.70 (m, IH), 7.79 (d, J = 1.6 Hz, IH), 7.56 (d, J = 8.4 Hz, IH), 7.26-7.23 (m, IH), 4.26 (5, 2H), 3.49-3.46 (m, 4H), 3.18- 3.13 (m, 4H), 1.43 (5, 9H). LCMS: (Method A) 318.0 (M+H), Rt. 2.26 mm, 39.9% (Max).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromoisoindolin-1-one, other downstream synthetic routes, hurry up and to see.