Reference of 32692-19-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32692-19-6, name is 5-Nitroindoline, This compound has unique chemical properties. The synthetic route is as follows.
A. Synthesis of tert-butyl 5-nitro-2,3-dihvdro-1H-indole-1-carboxylate. To a stirred solution of 5-nitroindoline (0.50 g, 3.0 mmol) and di-tert-butyl dicarbonate (0.97 g, 4.4 mmol) in anhydrous tetrahydrofuran (10 mL) was added 4- dimethylaminopyridine (0.054 g, 0.44 mmol) at ambient temperature. The reaction mixture was stirred at 60 0C for three hours. Water was added slowly to quench the reaction. The reaction mixture was poured into saturated sodium bicarbonate solution (100 mL). The mixture was extracted with ethyl acetate (3 x 30 mL). The combined organic layers was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to give tert-butyl 5-nitro-2,3-dihydro-1H-indole-1 -carboxylate (0.77 g, 98%) as a brown solid: 1H NMR (300 MHz, CDCI3) delta 8.07 (dd, J = 9.0, 2.4 Hz, 1 H), 7.97 (d, J = 1.2 Hz, 1 H), 7.94-7.50 (br, 1 H), 4.06 (t, J = 8.8 Hz, 2H), 3.14 (t, J = 8.8 Hz, 2H), 1.55 (s, 9H).
The chemical industry reduces the impact on the environment during synthesis 5-Nitroindoline. I believe this compound will play a more active role in future production and life.