39755-95-8, Name is 5-Methoxyisatin, 39755-95-8, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
5-Methoxyisatin (2.00 g, 11.2 mmol) was dissolved into 47% hydrobromic acid (20 mL) and refluxed at 150 C for 3 h. The solution was diluted with water (100 mL) and extracted by ethyl acetate (300 mL ¡Á 5). The organic layers were combined and dried with anhydrous sodium sulfate. After concentration in vacuo, the crude dark-brown solid (1.64 g, 89% yield) was obtained. In the subsequent synthesis, 5-hydroxyisatin was used without further purification. 1H NMR (CD3OD, 500MHz) delta 6.78 (d, 1H, J=8.3Hz, H-7), 6.94 (d, 1H, J=2.4Hz, H-4), 7.02 (dd, 1H, J=8.3, 2.4Hz, H-6).
Statistics shows that 5-Methoxyisatin is playing an increasingly important role. we look forward to future research findings about 39755-95-8.
Reference:
Article; Yasuda, Daisuke; Takahashi, Kyoko; Ohe, Tomoyuki; Nakamura, Shigeo; Mashino, Tadahiko; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7709 – 7714;,
Indoline – Wikipedia,
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