Some common heterocyclic compound, 6780-38-7, name is 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride, molecular formula is C10H6ClNO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(1,3-Dioxoisoindolin-2-yl)acetyl chloride
To a solution of the starting material 5-2 (50 mg, 0.2 mmol) and triethylamine (60 mul_, 2 eq) in 1 mL of dioxane at 0 0C was added phthalyl-glycyl chloride (44 mg, 1 eq) in 1 ml_ of dioxane. The resulting solution was stirred at room temperature overnight. The solution was then evaporated. Water was added and the product was extracted in ethyl acetate (X3) to give 77 mg (88% yield) of 11a, LC-MS 440 (MH+). This material was converted to the free amine 11-1 as described in Step 4C. LC-MS (method 2) 310.1 (MH+), tR = 3.44 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6780-38-7, its application will become more common.