Related Products of 496-12-8, A common heterocyclic compound, 496-12-8, name is Isoindoline, molecular formula is C8H9N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step two:Add to 50mL DMSO7-(4-Chlorophenyl)-1,8-naphthyridin-2-ylcarbamate (5.0 mmol) and isoporphyrin(5.5mmol),Stir at 80 C overnight.The reaction mixture was quenched with water (200 mL)Combine the organic phase,Wash with saturated sodium chloride solution,Dry over anhydrous sodium sulfate,filter,The residue was purified by silica gel column chromatography (hexane: methanol:Obtain a title in the form of a white solidCompound 1.59g,The yield was 79.6%.
The synthetic route of 496-12-8 has been constantly updated, and we look forward to future research findings.