Some common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione
1360 g of 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-iso-indole-1,3(2H)-dione (VI) are suspended in 10.2 l of ethanol at 22 C., and 1103 g of methylamine solution (40% strength in water) are added. The reaction mixture is then heated to 60 to 63 C., and the resulting solution is stirred at this temperature for 2 hours. After cooling to 55 to 60 C., a total of 2348 g of hydrochloric acid solution (20% strength in water) is added until the pH is 2.7, after which the product starts to crystallize. After cooling to 20 C., the precipitated reaction product is filtered off with suction, washed with methanol and then dried. Yield: 875 g; equivalent to 82.7% of theory. Melting point: decomposition above 280 C. 1H NMR (300 MHz, d6-DMSO): 3.25 (m, 2H), 3.72 (m, 2H), 3.98 (m, 3H), 4.42 (m, 3H), 4.97 (m, 1H), 7.42 (d, 2H, J=9.0 Hz), 7.57 (d, 2H, J=9.0 Hz), 8.44 (s (br.), 3H) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 446292-08-6, its application will become more common.