Related Products of 7699-18-5, A common heterocyclic compound, 7699-18-5, name is 5-Methoxyindolin-2-one, molecular formula is C9H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 4.4.14 (Z)-3-((2-(3,5-difluorophenyl)-1H-benzo[d]imidazol-6-yl)methylene)-5-methoxyindolin-2-one (5n) Compound 5n was prepared according to the method described for compound 5a, employing aldehyde 11d (129 mg, 0.5 mmol) and 5-methoxyindolin-2-one (12b, 81 mg, 0.5 mmol) to obtain the pure product 5n as a yellow solid (110 mg, 55%); mp: 296-298 C; IR (KBr): 3425, 3165, 2925, 2357, 1673, 1640, 1560, 1410, 1282, 1190, 1120, 942, 866, 745 cm-1; 1H NMR (300 MHz, DMSO-d6): delta 10.69 (bs 1H), 8.04 (s, 1H), 7.91 (s, 3H), 7.75 (s, 1H), 7.62 (s, 2H), 7.47 (t, J = 7.9 Hz, 1H), 7.05-6.87 (m, 2H), 3.79 (s, 3H); 13C NMR (75 MHz, CDCl3 + DMSO-d6): delta 168.8, 164.4 and 161.3 (d, J = 246.1 Hz), 163.7 and 161.7 (d, J = 246.1 Hz) 160.7,154.6, 149.7, 141.2, 137.5, 134.6, 128.7 (d, J = 4.9 Hz), 127.6, 125.4, 124.8, 122.7, 120.6, 118.6, 109.8, 109.4, 105.7, 55.2; MS (ESI): m/z 404 [M + H]+; HRMS (ESI): calcd for C23H16O2N3F2 m/z 404.12308 [M + H]+; found 404.12758.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kamal, Ahmed; Nagaseshadri; Nayak, V. Lakshma; Srinivasulu, Vunnam; Sathish, Manda; Kapure, Jeevak Sopanrao; Suresh Reddy; Bioorganic Chemistry; vol. 63; (2015); p. 72 – 84;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem