Synthetic Route of 446292-08-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
2 – ({(5S) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -1,3-oxazolidin-5- yl} methyl) -1,3 (2H) -dione (Formula 5) was suspended in 75 ml of ethanol at 22 , and 8.1 g of a methylamine solution (concentration in water of 40%) was added.The reaction mixture was then heated to 60-63 C and stirred at this temperature for 2 hours.After cooling to 55-60 & lt; 0 & gt; C, a total of 14.6 g of a solution of bromic acid (47% in water) was added until the pH was 2.7. After confirming that the crystallization of the product started, the precipitated reaction product was filtered off under suction, washed with methanol, and then dried at 50 DEG C for 4 hours to obtain 7.3 g of the desired product (Yield: 82.6%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IL DONG PHARMACEUTICAL CO., LTD.; LEE, Ki Yong; KWON, Jae Wook; SEO, Myeong Won; KANG, Jae Hoon; (15 pag.)KR2017/98031; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem