Some common heterocyclic compound, 205383-87-5, name is tert-Butyl 2-oxospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate, molecular formula is C16H20N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of tert-Butyl 2-oxospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate
A mixture containing commercially available tert-butyl 2-oxospiro [indoline-3, 3′-pyrrolidine] -1′-carboxylate (391 mg, 1.36 mmol) and NBS (290 mg, 1.63 mmol) in THF (5 mL) was heated to reflux and stirred for 20 h. The reaction mixture was then cooled, quenched with water, and extracted with EtOAc. The organic layer was concentrated and purified by chromatography on SiO2(2-20MeOH/DCM) to provide tert-butyl 5-bromo-2-oxospiro [indoline-3, 3′-pyrrolidine] -1′-carboxylate. MS (EI) calc’d for C16H20BrN2O3[M+H]+, 367 found, 367.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 205383-87-5, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; CHRISTOPHER, Matthew P.; FRADERA LLINAS, Francesc Xavier; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; XU, Shimin; FU, Jianmin; FU, Ning; LI, Yabin; WANG, Xichao; (228 pag.)WO2017/166104; (2017); A1;,
Indoline – Wikipedia,
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