3484-35-3, Adding a certain compound to certain chemical reactions, such as: 3484-35-3, name is 5-Methylindolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3484-35-3.
General procedure: To a solution of hydrazide 4 (10 mmol, 0.36 g) in ethanol (20 mL), the appropriate isatin (10 mmol) was added followed by a catalytic amount of acetic acid (0.5 mL) then the mixture was refluxed for 1 h. The formed precipitate was filtered off, washed with hot ethanol and recrystallized from DMF/ EtOH to give the targeted compounds 5a-d. 4.1.3.4 4-(3-(2-(5-Methyl-2-oxoindolin-3-ylidene)hydrazine-1-carbonyl)-5-phenyl-1H-pyrazol-1-yl)benzenesulfonamide (5d) Yellow powder, 77% yield; mp > 300 C. IR (KBr) numax/cm-1 3344-3215 (NH2, NH), 1714, 1685 (C=O), 1517 (C=N), 1340, 1166 (SO2). 1H NMR (DMSO-d6, 300 MHz) delta 2.30 (s, 3H, CH3), 6.83 (d, 1H, J = 7.9 Hz, H-7 of isatin), 7.17 (d, 1H, J = 7.9 Hz, H-6 of isatin), 7.26 (s, 1H, H-4 of pyrazole), 7.27-7.35 (m, 5H, Ar-H), 7.49 (s, 2H, SO2NH2, D2O exchangeable), 7.57 (d, 2H, J = 8.1 Hz, Ar-H), 7.65 (d, 1H, J = 7.8 Hz, H-4 isatin), 7.91 (d, 2H, J = 8.7 Hz, Ar-H), 10.81, 11.22 (2s, 1H, NH isatin, D2O exchangeable), 11.54, 14.13 (2s, 1H, NH hydrazone, D2O exchangeable). 13C NMR (DMSO-d6, 75 MHz) delta 20.48 (CH3), 109.07, 110.87, 119.88, 121.29, 125.37, 125.90, 126.69, 128.54, 129.21, 131.68, 132.13, 138.08, 140.28, 141.34, 143.91, 145.43, 157.50, 162.61. MS m/z [%] 500 [M+, 5.60], 222 [100]. Anal. Calcd for C25H20N6O4S (500.53): C, 59.99; H, 4.03; N, 16.79; S, 6.41. Found: C, 60.23; H, 4.11; N, 16.93; S, 6.46.
According to the analysis of related databases, 3484-35-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ibrahim, Hany S.; Abou-Seri, Sahar M.; Tanc, Muhammet; Elaasser, Mahmoud M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 583 – 593;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem