A common heterocyclic compound, 4702-13-0, name is N-Phthaloylglycine, molecular formula is C10H7NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 4702-13-0.
Commercially available N-phthaloylglycine (32, 200mg, 0.975mmol) was dissolved in SOCl2 (2.84mL) and refluxed for 2h. After evaporation of the solvent under reduced pressure, the obtained white solid was solubilized in THF (1.7mL), and treated with tris(trimethylsilyl)phosphite (978muL, 2.92mmol) at 0C for 15min, and then stirred at room temperature for 15min. Methanol (4mL) was added and the solution was stirred for 1hat room temperature. The solvent was evaporated under vacuum and the white solid was washed three times with a toluene/hexane mixture (1:1) (4mL), washed with Et2O and dried under vacuum, obtaining the intermediate 37. Yield: 337mg (98.5%).
The synthetic route of N-Phthaloylglycine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Savino, Salvatore; Toscano, Annamaria; Purgatorio, Rosa; Profilo, Emanuela; Laghezza, Antonio; Tortorella, Paolo; Angelelli, Mariacristina; Cellamarea, Saverio; Scala, Rosa; Tricarico, Domenico; Thomas Marobbio, Carlo Marya; Perna, Filippo; Vitale, Paola; Agamennone, Mariangela; Dimiccoli, Vincenzo; Tolomeo, Anna; Scilimati, Antonio; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 184 – 200;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem