Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 875003-43-3, name is 7-Fluoro-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Computed Properties of C9H6FNO2
General procedure: A solution of 6-fluoro-1-methylindolin-2-one (Step B12.2) (255 mg, 1.235 mmol) in DMF (10 ml.) was cooled down to 0C and NBS (286 mg, 1.606 mmol) was added. The resulting mixture was allowed to warm up to RT then, heated up and stirred at 80C for 2 hr. The reaction mixture was diluted with EtOAc and washed with aqueous NaHC03 solution, 0.1 M LiBr and brine. The organic layer was dried over MgS04, filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography on silica gel (cyclohexane / 20 to 100% EtOAc) to afford the title product (222 mg, 0.591 mmol, 47.9% yield). Rt = 0.87 min (UPLC-MS); ESI-MS = 243.9 / 245.9 [M+1] + (UPLC-MS).
The synthetic route of 875003-43-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; ARISTA, Luca; CHAMOIN, Sylvie; D’ALESSANDRO, Pier Luca; LINDVALL, Mika; LIZOS, Dimitrios; STIEFL, Nikolaus Johannes; TEIXEIRA-FOUCHARD, Sylvie; ULLRICH, Thomas; WEILER, Sven; (151 pag.)WO2019/102256; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem