Electric Literature of 446292-08-6,Some common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 2000 ml 4 neck RBF, charge Isopropanol (1000 ml), Methyl amine 33% solution in methanol (1000 ml) and 100 gms compound (III). Stirr the reaction mass at 55-60C for 5 hrs. Cool the reaction mass at 25-30C and stirr for 1 hr. Filter the reaction mass and wash with Isopropanol (50 ml). Dry the solid at 45-50C under vacuum. Dry Wt: 55 gms (Theoretical yield: 79.60%); Purity: 97.70%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; MEHTA API PVT. LTD.; KHAN, Rao, Uwais, Ahmad; SONI, Amit Manohar; MALI, Sanjay, Gunda; (29 pag.)WO2016/199027; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem