Discovery of N-(2-Oxoethyl)phthalimide

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2913-97-5, name is N-(2-Oxoethyl)phthalimide, This compound has unique chemical properties. The synthetic route is as follows., 2913-97-5

Step 2: A mixture of aniline 107 (1 37 g, 6 7 mmol), 2-(l,3-dioxoisoindohn-2-yl)acetaldehyde (108)(1 26 g, 6 7 mmol), sodium tnacetoxyborohydnde (2 1 g, 10 05 mmol), and acetic acid (0 04 g, 6 7 mmol) in dry dichloromethane under argon was stirred at room temperature for 2 h The reaction mixture was washed with saturated aqueous NaHCO3, water, and brine The combmed organics were dried over Na2SO4 filtered, and concentrated under reduced vacuum Flash chromatography (0-60percent EtOAc – hexanes gradient), gave the secondary aniline 109 as a yellow oil Yield (1 6 g, 64percent) 1H NMR (400 MHz, CDCl3) delta 7 80 – 7 85 (m, 2H), 7 66 – 6 72 (m, 2H), 7 01 (t, J = 6 Hz, IH)1 6 18 – 6 22 (m, 2H), 6 14 – 6 18 (m, IH), 4 05 (br s, IH), 3 95 (t, J= 6 0 Hz, 2H), 3 68 (d, /= 6 4 Hz, 2H), 3 41 (t, J= 6 4 Hz, 2H), 1 80 – 1 88 (m, 2H), 1 64 – 1 78 (m, 4H), 1 12 – 1 34 (m, 3H), 0 96 – 1 08 (m, 2H)

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Reference:
Patent; ACUCELA INC.; WO2009/45479; (2009); A1;,
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