The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 496-12-8, name is Isoindoline, A new synthetic method of this compound is introduced below., Product Details of 496-12-8
To a solution of isoindoline (335 mg, 2.8 mmol) in DCM (5 ml) is added a 2M solution of trimethylaluminum in toluene (1.4 ml, 2.8mmol) and the resulting solution is allowed to EPO stir at ambient temperature for 30 minutes and is then added to a solution of 2-tert- butoxycarbonylamino-3-(2-chloro-3,4-dimethoxy-phenyl)-propinoic acid methyl ester (520 mg, 1.39 mmol) in DCM (5 ml). The reaction is allowed to stir at ambient temperature for 18 h and carefully quenched with a 10% aqueous solution of citric acid. The resulting biphasic mixture is diluted with DCM (20 ml) and extracted with a saturated solution of Rochelle’s Salt (20 ml). The organic layer is separated, concentrated in vacuo and purified by column chromatography (hexanes-ethyl acetate 15- 60%) resulting in 2-tert-Butoxycarbonylamino -3-(2-chloro-3,4-dimethoxy-phenyl)-l-(l,3-dihydro- isoindol-2-yl)-propan-l-one (300 mg, 47%). 2-tert-Butoxycarbonylamino -3-(2-chloro-3,4- dimethoxy-phenyl)-l-(l,3-dihydro-isoindol-2-yl)-propan-l-one is analyzed by HPLC/Mass Spec.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/38459; (2007); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem