Electric Literature of 496-12-8, These common heterocyclic compound, 496-12-8, name is Isoindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Isoindoline 228 Milligram (mg) ( (1.91 mmol, mmol) was dissolved in dimethylformamide Dissolved in 20 milliliters (mL) 153 mg of 55% (v / v) sodium hydride at 0 C (3.52 mmol) was added thereto, followed by stirring for about 40 minutes, 3 – ((2S, 3R, 4R, 5S, 6R) -3,4,5-triacetoxy-6-acetoxymethyl-tetrahydropyran -2-yl] benzyl bromide 800 mg (1.60 mils Mol) was added and the mixture was stirred at room temperature for about 10 hours. 100 milliliters of water was added to the reaction mixture, and the mixture was extracted with ethyl acetate Dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by column chromatography to give 420 mg (yield: 70.7%) of the title compound was obtained.
The synthetic route of 496-12-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samjin Pharmaceutical Co., Ltd.; Cho, Eui-Hwan; Shin, Hui-Jong; Kwon, Ho-Seok; Lee, Jae-Woong; Joo, Jeong-Ho; Lee, Keun-Kuk; Kim, Jong-Min; Kim, Hyun-Tae; Kim, Jae-Eon; Lee, Jung-Rok; Jang, Beom-Hyeon; (37 pag.)KR2016/97861; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem