Reference of 20876-36-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20876-36-2 name is 5-Aminoindolin-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Condensation of oxindoles with quinoline-N-oxides: An oxindole (1.6 mmol) may be taken up in acetic anhydride (10 mL) and a solution of quinoline-N-oxide (0.474 mmol) and 5 mL of acetic anhydride may be added. This solution may then be heated at between 0-150¡ãC for between 1-25 hours. In one variation, the reaction is conducted at about 90 ¡ãC for about 3 hours. The resulting solution may then be cooled to room temperature. If a solid is observed upon cooling, the material may be isolated by filtration and washed with a minimal amount of cold MeOH, then dried in vacuo. If no solid is observed upon cooling, the reaction may be diluted with an organic solvent, such as ethyl acetate, washed with brine several times, dried over MgSO4 and concentrated to afford an oil. Purification by preparative HPLC may afford a solid product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Aminoindolin-2-one, and friends who are interested can also refer to it.
Reference:
Patent; SYRRX, INC.; WO2005/61519; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem