Synthetic Route of 1035235-27-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1035235-27-8, name is tert-Butyl 4-bromoisoindoline-2-carboxylate belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of tert-butyl 4-bromoisoindoline-2-carboxylate (1.00 g, 3.37mmol), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi(1 ,3,2-dioxaborolane) (1.03 g, 4.04 mmol), AcOK (661 mg, 6.74 mmol) and Pd(dppf)C12 (50.0 mg) in dioxane (20 mL) was stirred at 90C lbr 16 h under the nitrogen atmosphere. After cooling down to 20C and LCMS showed the reaction was complete, the mixture was filtered and the filtrate was concentrated under reduced pressure to get the title compound (1.2 g, yield 103%) as a brown solid, which was directly to the next step without further purification ?HNMR(CDC13, 400 MHz) oe 7.69 (d, J 7.2 Hz, 1 H) 7.36-7.27 (m, 2 H) 4.87-4.63 (m, 4 H) 1.52 (s, 9 H) 1.31 (s, 12 H).
The synthetic route of tert-Butyl 4-bromoisoindoline-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KADMON CORPORATION, LLC; KIM, Ji-in; LIU, Kevin; POYUROVSKY, Masha; LU, Dan; ZHU, Zhenping; WO2015/54317; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem