Some common heterocyclic compound, 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, molecular formula is C10H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C10H9NO3
To a suspension of 3.0 g (7.84 mmol) of pyrimidinone A, 4.12 g (15.7 mmol) of triphenylphosphine and 4.12 g (15.7 mmol) of N-(2-hydroxyethyl)-phthalimide in 45 ML of 1,4-dioxane at 5 C. was added dropwise a solution of 2.73 g (2.5 ML, 15.7 mmol) of diethylazodicarboxylate in 10 ML of 1,4-dioxane over a period of 20 min. through an additional funnel.The suspension was stirred at 5 C. for 1 hour and then at room temperature overnight at which point the suspension turned into a yellow solution.The solution was concentrated in vacuo and the residue was purified by column chromatography with silica eluding with 7.5% ethyl acetate in dichloromethane affording 3.92 g of the phthalimide 1 (90% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3891-07-4, its application will become more common.
Reference:
Patent; Goldstein, David Michael; Hawley, Ronald Charles; Lui, Alfred Sui-Ting; Sjogren, Eric Brian; US2003/232847; (2003); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem