In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32372-82-0 as follows. category: indolines-derivatives
Isoindoline hydrochloride (31.1 mg, 0.2 mmol), graphene oxide (8 mg),And a stirrer is placed in the reaction tube, after replacing the inert gas,Add 1 ml of DMF and seal the reaction tube. Place the reaction tube at 150CIn the oil bath, stir the reaction for 18 hours; after cooling to room temperature,The catalyst was removed by filtration and the filtrate was diluted with 15 mL of water.And extracted with ethyl acetate 3 times, each time 15mL; combined extract,Dry with anhydrous sodium sulfate and filter. The filtrate is concentrated under reduced pressure.The crude product was purified by column chromatography with ethyl acetate:petroleum ether=1:3 (containing 1% triethylamine) as eluent. Black oil, 42% yield
According to the analysis of related databases, 32372-82-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xiangtan University; Gong Xing; Xie Guilin; Cai Changqun; Zhang Jingyu; (19 pag.)CN107827816; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem