Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 366453-22-7, name is 4-Methoxyisoindolin-1-one, A new synthetic method of this compound is introduced below., category: indolines-derivatives
Step c: To an ice-cold solution of [11C] (291 mg, 1.78 [MMOL)] in CH2CI2 (20 mL) was added a 1.0 M BBr3 solution in [CH2CI2] (3.6 mL, 3.6 [MMOL).] The cold bath was then removed and the resulting solution was stirred for 16 h at ambient temperature. The reaction was carefully quenched by the addition of water and the mixture was extracted with EtOAc. The combined extracts were washed with water and brine, dried [(MGS04),] filtered and evaporated to dryness to give [11D] (232 mg, 87% yield) as beige solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM (CANADA) LTD.; WO2004/26875; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem