Adding a certain compound to certain chemical reactions, such as: 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 446292-08-6, Application In Synthesis of (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione
In a four neck round bottom flask, charged methanol (2900 ml), 2-([(5S)-2- Oxo-3-[4-(3-oxo- 4-morpholinyl)phenyl]-l,3-oxazolidin-5-yl}methyl)-lH-isoindole-l,3(2H)-dione (290 g), and 40% aqueous methylamine (265 g) at 25 to 30C. Reaction mass is stirred for 1 h at 25 to 30C and then heated to 60 to 65C, and maintained at same temperature for 4 h. Reaction mixture then cooled to 25 to 30C and added cone, hydrochloric acid (290 ml, pH should be 1 to 2) and stirred for 30 minutes. Obtained solid is filtered off and washed by chilled methanol (290ml). Yield= 92.0%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WANBURY LTD.; DR. NITIN SHARADCHANDRA PRADHAN; DR. NILESH SUDHIR PATIL; DR. RAJESH RAMCHANDRA WALAVALKAR; MR. NILESH SUBHAS KULKARNI; MR. SANDIP BABANRAO PAWAR; MR. TARAK SAMBHAJI PAWAR; WO2014/102820; (2014); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem