The synthetic route of 3485-84-5 has been constantly updated, and we look forward to future research findings.
In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3485-84-5, name is N-Vinylphthalimide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: N-Vinylphthalimide
A thick walled glass tube, equipped with a stir bar, was charged with palladium (II) acetate (17 mg, 0.08 mmol), acetonitrile (50 mL), vV-vinylphthalimide (716 mg, 4.13 EPO mmol), triethylamine (1.6 niL, 11 mmol), tri-o-tolylphosphine (69 mg, 0.22 nimol) and 1- {3-[8-bromo-2-(2-methoxyethyl)-lH’-imidazo[4,5-c]quinolin-l-yl]propyl}pyrrolidin-2-one (1.62 g, 3.76 mmol). The reaction mixture was purged with nitrogen and the tube was sealed and heated at 1200C in an oil bath for 15 hours. The reaction was cooled to ambient temperature and methanol (50 niL) and chloroform (50 ml) were added. After filtering through a 0.2 micron PTFE membrane, the solution was concentrated under reduced pressure and then purified by chromatography using a HORIZON HPFC system (silica cartridge, eluting with a 0-8% gradient of methanol in dichloromethane) to provide 2.0 g of2-(2-{2-(2-methoxyethyl)-l-[3-(2-oxopyrrolidin-l-yl)propyl]-lH-imidazo[4,5- c]quinolin-8-yl}ethenyl)-lH-isoindole-l,3(2H)-dione as a bright yellow solid. MS (APCI) m/z 524 (M + H)+.
The synthetic route of 3485-84-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2006/91394; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem