64483-69-8, name is 5-Acetylindolin-2-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5-Acetylindolin-2-one
5-Ethyl-2-oxindole To 5-Acetyl-2-oxindole (2 g) in 15 ML of trifluoroacetic acid in an ice bath was slowly added 1.8 g of triethylsilane; the reaction was then stirred at room temperature for 5 hours.. One ML of triethylsilane was added and the stirring continued overnight.. The reaction mixture was poured into ice water and the resulting precipitate collected by vacuum filtration, washed copiously with water and dried under vacuum to give 1.3 g (71% yield) of the title compound as a yellow solid.
The synthetic route of 64483-69-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sugen, Inc.; US6350754; (2002); B2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem