324-03-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 324-03-8 as follows.
To a 250 mL round-bottom flask was added 6-fluoro-2,3-dihydro-lH-indole-2,3-dione (8 g, 48.45 mmol, 1.0 equiv.), iodomethane (15.1 g, 106.38 mmol, 2.2 equiv.), potassium carbonate (26.7 g, 193.18 mmol, 4.0 equiv.), and CH3CN ( 150 mL). The resulting mixture was stirred overnight at 60 C. The reaction was quenched with water. The resulting solution was extracted with ethyl acetate (100 mL x 3); and the combined organic layers were washed with brine (50 mL x 2), dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified via silica gel column chromatography eluting with ethyl acetate/petroleum ether (20%-40%) to give 6-fluoro-l-methyl-2,3-dihydro-lH-indole-2,3-dione 30b (7 g, 81%) as a red solid.
According to the analysis of related databases, 6-Fluoroindoline-2,3-dione, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (249 pag.)WO2018/39384; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem