Adding some certain compound to certain chemical reactions, such as: 603-62-3, name is 3-Nitrophthalimide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 603-62-3. 603-62-3
Thiosalicylic acid (15.4 g, 0.1 mol) in NaOH aqueous solution (200 mL, 1 mol/L) was warmed until the solid dissolved, and then continually warmed to remove water. Ethanol was added into the sticky mixture, and then the white precipitates were collected by filtration, washed with ethanol, and dried in vacuo to obtain sodium thiosalicylate (f). A mixture of f (18.215 g, 0.1034 mol), 3-nitrophthalimide (15.892 g, 0.0827 mol), and DMF (200 mL) was stirred at 80 C for 8 h. A HCl solution (200 mL, 2 mol/L) was added. The precipitate was filtered, washed with water, dried in vacuo, and then recrystallized from dioxane to give a yellow powder. Yield: 95.4%. 1H NMR (300 MHz, DMSO-d6): delta 7.29-7.31 (m, 2H), 7.47 (m, 2H), 7.66 (m, 2H), 7.86 (m, 1H). Anal. Calcd. for C15H9NO4S: C, 60.19; H, 3.03; N, 4.68; S, 10.71; Found: C, 59.48; H, 3.20; N, 4.54; S, 10.51.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Nitrophthalimide.
Reference:
Article; He, Ming-Hui; Xu, Rui-Xin; Chen, Guang-Xue; Zeng, Zhao-Hua; Yang, Jian-Wen; Chinese Chemical Letters; vol. 25; 11; (2014); p. 1445 – 1448;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem