2058-72-2, The chemical industry reduces the impact on the environment during synthesis 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, I believe this compound will play a more active role in future production and life.
General procedure: To a flame-dried screw-capped test tube equipped with a magnetic stir bar was added 1, 4, 7, 10, 13, 16-hexaoxacyclooctadecane (0.396 g, 1.5 mmol), KF (0.087 g, 1.5 mmol) and 1- methylindoline-2,3-dione 3 (0.50 mmol). Then the screw-capped tube was evacuated and backfilled with argon. The mixture was dissolved in THF (2.0 mL) under argon atmosphere. The resultant reaction mixture was kept stirring at 30 C for 5 min. To the stirring solution was then added isoquinoline 1 (0.50 mmol) and the aryne precursor 2 (0.75 mmol). Then the reaction mixture was placed in preheated oil bath at 70 C. When TLC control showed the completion of the reaction (typically after 24 h), the reaction mixture cooled to room temperature and the solvent was evaporated and the crude residue was subsequently purified by flash column chromatography on silica gel to afford the corresponding spirooxazino isoquinoline derivatives (4) as an inseparable mixture of diastereomers in moderate to good yields. The dr was determined by 1H MR analysis of crude reaction mixture
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methylindoline-2,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; THANKAPPAN, Biju Akkattu; BHUNIA, Anup; ROY, Tony; WO2014/184808; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem