2058-72-2, A common compound: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
General procedure: A solution of isatin (0.035 mmol, 1.2 equiv), tryptamine (0.03 mmol, 1.0 equiv) and (R)-3,3′-bis(9-anthracenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate (0.006 mmol, 0.2 equiv) was prepared in dry CH2Cl2 (0.06 M) at 25 C in an oven-dried and Ar-purged 4 mL vial fitted with a magnetic stir bar. The reaction was stirred until it was complete as judged by TLC (80% EtOAc/hexanes). The reaction was then concentrated and loaded onto a flash silica gel column (gradient of EtOAc/hexanes ending in 80% EtOAc/hexanes) to afford the spiroindolone product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Badillo, Joseph J.; Silva-Garcia, Abel; Shupe, Benjamin H.; Fettinger, James C.; Franz, Annaliese K.; Tetrahedron Letters; vol. 52; 43; (2011); p. 5550 – 5553;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem