Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.99365-40-9, Name is 6-Bromoindolin-2-one, SMILES is O=C1NC2=C(C=CC(Br)=C2)C1, belongs to indolines-derivatives compound. In a document, author is Sagnou, Marina, introduce the new discover, Recommanded Product: 99365-40-9.
Novel Isatin Thiosemicarbazone Derivatives as Potent Inhibitors of beta-Amyloid Peptide Aggregation and Toxicity
Inhibition of beta-amyloid peptide (A beta) aggregation in Alzheimer’s disease (AD) is among the therapeutic approaches against AD which still attracts scientific research interest. In the search for compounds that interact with A beta and disrupt its typical aggregation course toward oligomeric or polymeric toxic assemblies, small organic molecules of natural origin, combining low molecular weight (necessary blood-brain barrier penetration) and low toxicity (necessary for pharmacological application), are greatly sought after. Isatin (1H-indoline-2,3-dione), a natural endogenous indole, and many of its derivatives exhibit a wide spectrum of neuropharmacological and chemotherapeutic properties. The synthesis and biological evaluation of four new isatins as inhibitors of A beta aggregation is presented herein. In these derivatives, the N-phenyl thiosemicarbazide moiety is joined at the 3-oxo position of isatin through Schiff base formation, and substitutions are present at the indole nitrogen and position 5 of the isatin core. Biophysical studies employing circular dichroism, thioflavin T fluorescence assay, and transmission electron microscopy reveal the potential of the isatin thiosemicarbazones (ITSCs) to alter the course of A beta aggregation, with two of the derivatives exhibiting outstanding inhibition of the aggregation process, preventing completely the formation of amyloid fibrils. Furthermore, in in vitro studies in primary neuronal cell cultures, the ITSCs were found to inhibit the A beta-induced neurotoxicity and reactive oxygen species production at concentrations as low as 1 mu M. Taken all together, the novel ITSCs can be considered as privileged structures for further development as potential AD therapeutics.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 99365-40-9 is helpful to your research. Recommanded Product: 99365-40-9.