Application of 99365-40-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 99365-40-9, Name is 6-Bromoindolin-2-one, SMILES is O=C1NC2=C(C=CC(Br)=C2)C1, belongs to indolines-derivatives compound. In a article, author is Luo, Kai, introduce new discover of the category.
Reaction of chloroauric acid with histidine in microdroplets yields a catalytic Au-(His)(2) complex
An aqueous solution containing histidine (His, 100 mu M) and chloroauric acid (HAuCl4, 10 mu M) is electrosprayed (-4.5 kV) from a capillary (50 mu m in diameter) with N-2 nebulizing gas (120 psi). The resulting microdroplets entered a mass spectrometer with a 2 cm flight path. The mass spectrum recorded in negative ion mode showed several peaks including the Au-5 nanocluster with the major one being [Au + 2His-2H](-), which is a catalytically active species. The reaction time was less 1 ms, and the yield of [Au + 2His-2H](-) was 76%. In contrast, the bulk reaction for the same concentration run at room temperature for 2 h did not produce this species but instead formed Au-10 nanocluster. When a solution of water and acetonitrile (1 : 1) containing indoline (100 mM) and the phenylacetylene (200 mM) as well as histidine and chloroauric acid at the same concentrations as above was electrosprayed, the mass spectrum showed the formation of the intermediate [Au + 2His + phenylacetylene + H](+). Upon collecting the microdroplets, the 4-methyl-4,6-diphenyl-1,2-dihydro-4H-pyrrolo[3,2,1-ij] quinolone product was observed by H-1 nuclear magnetic resonance and liquid chromatography with a yield of 44%. The microdroplet synthesis using the Au-(His)(2) complex as a catalyst was scaled up using room-temperature ultrasonic nebulization to produce the product at the rate of 35 mg min(-1), which is semi-preparative and demonstrates the promise of using microdroplet reactions for chemical synthesis.
Application of 99365-40-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 99365-40-9.