Application of 446292-08-6, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@H]2CN(C3=CC=C(N4C(COCC4)=O)C=C3)C(O2)=O)C(C5=C1C=CC=C5)=O, belongs to indolines-derivatives compound. In a article, author is Pagire, Santosh K., introduce new discover of the category.
Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of alpha,beta-unsaturated amides
An efficient cooperative chiral Lewis acid/photoredox catalytic system for engaging highly reactive radicals in highly enantioselective conjugate addition to alpha,beta-unsaturated carbonyls is highly desirable. Direct photoexcitation of unbound substrates typically induces undesired background pathways for racemic products and remains a formidable challenge to be addressed in the area of enantioselective photocatalysis. Herein, we report a cooperative catalytic system comprising a chiral Cu(I) complex and an Ir(III) photocatalyst fueled by visible-light irradiation that allows for seamless integration of the catalytic formation of alpha-amino alkyl radicals and subsequent enantioselective addition to alpha,beta-unsaturated amides. A 7-aza-6-MeO-indoline attachment on the amide substrates plays a pivotal role in suppressing the undesired pathways, resulting in excellent enantioselectivity and enabling expedited access to valuable gamma-aminobutyramides. The indoline amide was readily diversified with full recovery of the azaindoline attachment, highlighting the synthetic utility of this cooperative catalytic system.
Application of 446292-08-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 446292-08-6 is helpful to your research.