Application of 20870-78-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20870-78-4, name is 5-Bromoindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
5-(4,4,5,5-Tetramethyl-l,3,2-dioxaboroIan-2-yl)-l,3-dihydroindol-2-one; A mixture of 5-bromo-2,3-dihydroindol-2-one (500 mg), bis(pinacolato)diboron (899 mg) and potassium acetate (695 mg) in DMF (20 mL) was degassed for 5 minutes. 1,1′- 5 Bis(diphenylphosphino)ferrocenedichloropalladium(II) dichloromethane adduct (78 mg) was added to the mixture and the reaction was heated to 8O0C and left to stir for 3 hours. The reaction mixture was filtered through celite and concentrated in vacuo. The residue was suspended in water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The organics were dried (MgSO4), filtered and concentrated in vacuo to give the desired 0 material as a brown solid. (611 mg). Mass Spectrum; M+H+MeCN+ 301.NMR Spectrum: 1H NMR (DMSOd6) deltal.28 (12H, s), 3.47 (2H, s), 6.82 – 6.84 (IH, d), 7.51 (2H, m), 10.52 (IH, s)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromoindolin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/80382; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem