Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Aminoisoindoline-1,3-dione
Example 109 N-(1,3-Dioxo-2,3-dihydro-1H-5-isoindolyl)-N’-(2,3,6-trifluorobenzyl)urea Diphenylphosphoryl azide (173 mg, 0.63 mmol, 1.2 eq) and triethylamine (64 mg, 0.63 mmol, 1.2 eq) were added to a solution of 2,3,6-trifluorophenylacetic acid (100 mg, 0.53 mmol) in toluene, and the mixture was stirred at 110C for 60 min. Thereafter, 4-aminophthalimide (85 mg, 0.53 mmol, 1.0 eq) and a minor amount of DMF were added thereto, and the mixture was stirred at 110C for 3 hr. After the completion of the reaction, water and ethyl acetate were added thereto, and the precipitated crystal was collected by filtration and was washed with ethyl acetate to give the title compound as a crystal (100 mg, 54.6%). MS m/z: 349 1H-NMR delta: 4.43 (2H, d, J = 5.37 Hz), 6.98 (1H, t, J = 5.86 Hz), 7.11 – 7.18 (1H, m), 7.40 – 7.50 (1H, m), 7.58 (1H, dd, J = 1.83, 8.05 Hz), 7.66 (1H, d, J = 8.05 Hz), 7.98 (1H, d, J = 1.46 Hz), 9.21 (1H, s), 11.08 (1H, s)
The synthetic route of 3676-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1256574; (2002); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem