Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 552330-86-6, name is 5-Bromoisoindolin-1-one, A new synthetic method of this compound is introduced below., category: indolines-derivatives
A solution of 5-bromoisoindolin-1-one (2.0 g, 9.4 mmol) , N, N-dimethylpyridin-4-amine (0.23 g, 1.9 mmol) and di-tert-butyl dicarbonate (2.47 g, 11.3 mmol) in DMF (20 ml) was stirred at ambient temperature for 2 h. Water (100 mL) was then added and the mixture was extracted with EtOAc (3×30 mL) . The combined organic fractions were washed with brine (3×10 mL) , dried (Na2SO4) , filtered and the solvent evaporated under reduced pressure. The residue was purified by chromatography on SiO2(1-90EtOAc/isohexane) to give tert-butyl 5-bromo-1-oxoisoindoline-2-carboxylate. MS (EI) calc?d for C13H15BrNO3[M+H]+, 312 found, 312.
The synthetic route of 552330-86-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; CHRISTOPHER, Matthew P.; FRADERA LLINAS, Francesc Xavier; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; XU, Shimin; FU, Jianmin; FU, Ning; LI, Yabin; WANG, Xichao; (228 pag.)WO2017/166104; (2017); A1;,
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