Some common heterocyclic compound, 1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione, molecular formula is C13H11NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C13H11NO3
Reference Synthesis Example 221 (0990) 3-(1,3-Dioxoisoindolin-2-yl)cyclopenta-1-en-1-yl trifluoromethanesulfonate (0991) To a dichloromethane solution (30 mL) of 2-(3-oxocyclopentyl)isoindoline-1,3-dione (1.08 g, 4.71 mmol), trifluoromethanesulfonic acid anhydride (1.16 mL, 7.06 mmol) and N,N-diisopropylethylamine (1.16 mL, 9.42 mmol) were added at 0 C. and the resultant mixture was stirred at 0 C. for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to obtain the title compound (780 mg, yield 46%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1029691-06-2, its application will become more common.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; Saito, Noriko; Egi, Jun; Nagai, Hiroshi; Ueno, Megumi; Shintani, Yusuke; Inaba, Yusuke; Adachi, Michiaki; Hirai, Yuichi; Kawazu, Takeshi; Yasutake, Koichi; Takahashi, Daiki; (220 pag.)US9403798; (2016); B2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem