Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19727-83-4, name is 6-Nitroindoline, A new synthetic method of this compound is introduced below., Computed Properties of C8H8N2O2
l-(teri-Butylsulfinyl)-6-nitroindoline (SG4-017): To a solution of 6-nitroindoline (1.00 g, 6.09 mmol) and pyridine (1.48 mL, 18.27 mmol) in DCM (3 mL) was added a solution of t- butylsulfinyl chloride (0.751 mL, 6.09 mmol) at 0 C under Argon. The mixture was warmed to room temperature and stirred overnight. The reaction mixture was diluted with EtOAc (50 mL) and washed with HC1 (1 M aq. solution, 1 x 50 mL), water (1 x 50 mL), and brine (1 x 50 mL). The organic layer was dried ( a2S04) and concentrated under reduced pressure. The resulting residue was triturated using EtOAc/hexanes to provide the title compound as a dark yellow solid (1.252 g, 77%). Mp: 108 C (dec). NMR (400 MHz, CDCh) delta: 7.82 (dd, J= 8.1, 2.1 Hz, 1H), 7.67 (d, J= 2.1 Hz, 1H), 7.25 (d, J= 8.1 Hz, 1H), 4.36 (td, J= 10.5, 6.8 Hz, 1H), 3.60 (td, J = 10.5, 6.8 Hz, 1H), 3.30 (dddd, J= 17.3, 10.5, 6.8, 0.8 Hz, 1H), 3.17 (dddd, J= 17.3, 10.5, 6.8, 0.8 Hz, 1H), 1.34 (s, 9H). HPLC-MS (ESI+): m/z 559.3 [70%, (2M+Na)+], 291.2 [100%, (M+H)+].
The synthetic route of 19727-83-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; (257 pag.)WO2016/22460; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem