324-03-8, A common heterocyclic compound, 324-03-8, name is 6-Fluoroindoline-2,3-dione, molecular formula is C8H4FNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 5.0 g (30.3 mmol) 6-fluoro-1 H-indole-2,3-dione in 75 mL of 33% aq. potassium hydroxide solution was added 4.67 g (53.0 mmol) pyruvic acid and this mixture was heated at 40 C for 18 hours. After cooling to room temperature 10% aq. sulfuric acid was added (pH about 1 ). The formed solid was isolated by filtration and dried in vacuum. The solid was the desired 7-fluoroquinoline-2,4-dicarboxylic acid, which was used without further purification. Yield: 6.02 g (85%) 1H-NMR (300 MHz, DMSO d6) delta (ppm) = 7.78 (ddd, 1 H), 7.99 (dd, 1 H), 8.42 (s, 1 H), 8.89 (dd, 1 H).
The synthetic route of 324-03-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHMANN, Bernd; HEISLER, Iring; MUeLLER, Thomas; CLEVE, Arwed; HEROULT, Melanie; NEUHAUS, Roland; PETRUL, Heike; QUANZ-SCHOeFFEL, Maria; (194 pag.)WO2016/12474; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem