Application of 99365-40-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99365-40-9, name is 6-Bromoindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
The reaction condition is three: under the protection of nitrogen, the 6 – bromo indole -2 – ketone (212.0 mg, 1.0 mmol), potassium carbonate (276 mg, 2 mmol), tetrabutyl ammonium bromide (33 mg, 0.1 mmol) is placed in the dual-port reaction bottle. The good sealing of the reaction device, replacing the nitrogen three times, nitrogen balloon is inserted. Injection 22 ml tetrahydrofuran, in 85 C under stirring conditions for 30 min, then slowly injected into the 3 ml bromo hexane, maintain 85 C under stirring 8 h. To be reaction slowly cooling to the room temperature after quenching in the into ice water, dichloromethane is used for extracting the organic phase, deionized water after washing three times, the organic phase for water-free magnesium sulfate drying. After filtering the organic phase by the vacuum concentrated under reduced pressure to get the crude product, using column chromatography (eluate to DCM/PE=1:1) purification, to obtain white waxy solid compound 1 – hexyl -6 – bromo – indolone (172 mg), yield 58.1%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromoindolin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nanjing University of Posts and Telecommunications; Lai Wenyong; Meng Cheng; Li Xiangchun; Huang Wei; (19 pag.)CN108794494; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem