Extended knowledge of 19155-24-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,3-Dimethylindolin-2-one, and friends who are interested can also refer to it.

Reference of 19155-24-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19155-24-9 name is 3,3-Dimethylindolin-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1 5-amino-l-ethyl-3,3-dimethylindolin-2-one; Compound a (38.4 g), prepared according to the procedures described in Robertson et.al. (J. Med. Chem. 29(10) 1832-1840 (1986)), was dissolved in 300 ml of cone, sulfuric acid using mechanical stirring and cooled using a -40 C cooling bath until stirring became difficult. A solution of 10.1 ml of fuming nitric acid and 50 ml of cone, sulfuric acid was added dropwise and the reaction allowed to warm to ambient temperature with stirring for 12 hours. The reaction mixture was poured into ice water and compound b was collected by filtration and dried (yield: 3Ig).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,3-Dimethylindolin-2-one, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; WO2007/120339; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem