Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 480-91-1, name is Isoindolin-1-one, A new synthetic method of this compound is introduced below., 480-91-1
Phthalimidine (1.60g, 12.0mmol) was dissolved in THF (80mL). Triethylamine (1.34g, 13.2mmol) was added dropwise and the mixture was stirred for 5min at ambient temperature. Chlorodiphenylphosphine (2.65g, 12.0mmol) was added and the mixture was stirred for three days, whereupon the white precipitate was filtered and washed with THF (2¡Á3mL). The combined filtrate and washings were evaporated to dryness (condensation of volatiles into a cold trap under reduced pressure) and the residue was recrystallized from THF (27.5mL). The white crystalline product was suitable for single-crystal X-ray diffraction. The supernatant was decanted, the white solid was washed with Et2O (3mL) and dried in vacuo to yield 2.33g (7.34mmol, 61%) of 1b. (0014) Anal. Calc. for C20H16NOP (MW: 317.3), requires: C, 75.70; H, 5.08; N, 4.41. Found: C, 75.83; H, 5.18; N, 4.43%. 1H NMR (CDCl3, delta ppm): 4.18 (s, -CH2-, 2H), 7.33 (d, J=7.54Hz, aryl, 1H), 7.38-7.50 (br. m, aryl, 11H), 7.54 (dt, J=7.45Hz, J=1.10Hz, aryl, 1H), 7.94 (d, J=7.54Hz, aryl, 1H). 13C{1H} NMR (CDCl3, delta ppm): 49.2 (d, J=7.1Hz), 123.0 (s), 124.6 (s), 128.2 (s), 128.7 (d, J=6.2Hz), 129.6 (s), 132.1 (s), 132.2 (s), 132.5 (d, J=21.1Hz), 135.7 (d, J=14.4Hz), 143.8 (s), 173.3 (d, J=17.3Hz), 31P{1H} NMR (CDCl3, delta ppm): 29.7 (s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Gericke, Robert; Wagler, Joerg; Polyhedron; vol. 120; (2016); p. 134 – 141;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem