Reference of 446292-08-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 446292-08-6 as follows.
Add 28 kg of rivaroxaban intermediate IV to 280 L of absolute ethanol, and add 36.5 kg of 40% methylamine solution.After refluxing for 1 h, the temperature was lowered to 50-60 C.Add 6N hydrochloric acid to adjust the pH to 2~3,Cool down to room temperature, centrifuge,Drying the filter cake to obtain rivaroxaban intermediate V(4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride) 19.66kg,The yield is 90.3%,The purity is 99.78%.
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Qilu Pharmaceutical Co., Ltd.; Fan Chuanwen; Leng Chuanxin; Wang Yubing; Liu Peiyuan; (6 pag.)CN109553611; (2019); A;,
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