These common heterocyclic compound, 99365-40-9, name is 6-Bromoindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6BrNO
bl .l) 2-Oxoindoline-6-carbonitrile A mixture of palladium-tetrakis(triphenylphosphine) (10.90 g, 9.43 mmol), 6- bromoindolin-2-one (10 g, 47.2 mmol) and dicyanozinc (7.75 g, 66.0 mmol) in DMF (80 mL) was heated to 80 C for 16 h. The reaction mixture was cooled to rt and water was added. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2S04, filtered, and concentrated under reduced pressure. The crude material was purified by column chromatography (silica gel column and elution with 5% MeOH/CfLC^) to give 2-oxoindoline-6-carbonitrile (5.97 g, 37.7 mmol, 80 % yield) as a brown solid. RT=1.15 min (3 min).
The synthetic route of 6-Bromoindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE DEUTSCHLAND GMBH & CO. KG; GENESTE, Herve; HORNBERGER, Wilfried; JANTOS, Katja; KLING, Andreas; VAN GAALEN, Marcel; (122 pag.)WO2015/173393; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem